About Epididymo-orchitis

  • Epididymo-orchitis is an inflammation (usually unilateral) of the epididymis that can also affect the adjacent testicle.1,2
  • The STIs chlamydia and gonorrhea are common causes in people aged <35 years. Enteric pathogens (eg, Escherichia coli) can be transmitted via insertive anal sex. Other causes include urinary tract pathogens.
  • Recent onset pain and swelling are typical symptoms.


  • Physical examination to assess the location and characteristics of the pain
  • Take a urine specimen for microscopy, culture and sensitivity (mid stream) and/or first pass for chlamydia and gonorrhea nucleic acid amplification test.


  • For sexually active men, initiate presumptive antibiotic treatment for gonorrhea and chlamydia.
  • Click here for recommended antibiotic regimens and other management considerations. 

For detailed information about Epididymo-orchitis, see

Australian STI Management Guidelines: Epididymo-orchitis

MoCCA is funded by the National Health and Medical Research Council (APP1150014) and is a collaboration between the University of Melbourne and our project investigators and partner organisations in Victoria, New South Wales and Queensland. Click here for a list of our collaborators.

We acknowledge and pay respect to the Traditional Owners of the lands upon which this research is being conducted.